The UCSF Hair Analytical Laboratory (HAL) analyzes antiretroviral, anti-tuberculosis (anti-TB), antibiotic, and possibly controlled substance concentrations in hair (but may include other biological specimens such as urine, dried blood spot (DBS), plasma, serum, whole blood, nail, saliva, etc.) in the context of HIV and TB prevention and treatment studies using assays that are developed and validated according to the Federal Drug Administration (FDA’s) guidelines for bioanalytical methods and the National Institute of Health’s (NIH’s) Division of AIDS’ (DAIDS) Clinical Pharmacology Quality Assurance Program (CPQA). This position oversees and maintains high-quality regulatory functions in the laboratory.

Under supervision, the Staff Research Associate(SRA) typically performs a wide variety of standard repetitive procedures without detailed technical supervision, usually in a well-established occupational field (i.e., chemistry, microbiology, etc.). They may also modify, vary or adapt standard procedures to meet the needs of research projects or improve unsatisfactory tests, and after studying available literature, analyze and alter conditions under which determinations are made. They may also acquire and apply a body of knowledge and skill in a field of comparatively narrow scope where the emphasis is on specialized techniques

This HAL Staff Research Associate II position will assist senior analysts and train and mentor junior analysts to determine drug concentrations in samples utilizing validated high-performance liquid chromatographic (HPLC)-tandem mass spectrometric (LC/MS/MS) bioanalytical methods.

The purpose of this position is to design, develop, and execute a variety of analytical methods to quantitate antiretroviral, anti-TB, and antibiotic drugs and possibly controlled substances using liquid chromatography-tandem mass spectrometry (LC/MS/MS), primarily in hair samples (but may include other biological specimens, such as urine, dried blood spot, plasma, serum, whole blood, nail, saliva, etc.), for pharmacokinetic, compliance, and efficacy studies. Techniques may include, but are not limited to, protein precipitation, liquid-liquid extraction (LLE), and solid phase extraction (SPE). The successful candidate will have some knowledge and engage in analytical LC/MS/MS method development, validation, and the assaying of clinical samples in compliance with Food and Drug Administration’s (FDA’s) Good Laboratory Practice (GLP) and National Institute of Health’s (NIH’s) Division of AIDS’ (DAIDS) Clinical Pharmacology Quality Assurance (CPQA) regulatory guidelines.

In addition, will also be required to prepare Standard Operating Procedures (SOPs) and Analytical Validation Reports (AVR) for submission to Clinical Pharmacology Quality Assurance (CPQA); respond to inquiries from CPQA; train and mentor new staff members after successfully completing and understanding internal laboratory SOPs; operate and calibrate analytical instruments; use and calibrate micropipettes; prepare, analyze, run, and interpret data; and thoroughly document in lab books, log books, and paperwork.

To see the salary range for this position (we recommend that you make a note of the job code and use that to look up): TCS Non-Academic Titles Search (ucop.edu)

Please note: The compensation ranges listed online for roles not covered by a bargaining unit agreement are very wide, however a job offer will typically fall in the range of 80% - 120% of the established mid-point. An offer will take into consideration the experience of the final candidate AND the current salary level of individuals working at UCSF in a similar role.

For roles covered by a bargaining unit agreement, there will be specific rules about where a new hire would be placed on the range.

To learn more about the benefits of working at UCSF, including total compensation, please visit: https://ucnet.universityofcalifornia.edu/compensation-and-benefits/index.html

The Division of HIV, Infectious Diseases, and Global Medicine at the University of California, San Francisco (UCSF) is an internationally recognized global leader in clinical care, research and education. With its home base located at Zuckerberg San Francisco General Hospital (ZSFG), the Division has been ranked as the top facility in the country for AIDS care for over a decade.

The Division’s work is featured frequently in the media, and it is often visited by international, national, state and local dignitaries and delegations. The Division consists of approximately 36 faculty members and 140 academic and staff employees. It is the largest Division of the Department of Medicine (DOM) at ZFGH, with a total expenditure budget of approximately $45 million dollars

• BA/BS in a related science including one year of recent/directly related work experience following degree completion, utilizing techniques or methods required by the position and demonstrating technical expertise in these areas; or an equivalent combination of education and experience
• One year related scientific techniques and procedures as learned from academic laboratory or experimental field experience, especially utilizing LC-MS/MS systems (preferably Micromass Quattro Ultima (MassLynx software), Sciex API 5000 (Analyst software), and/or Agilent 6495 (MassHunter software) and HPLC systems
• Demonstrate reliability, organizational skills, attention to detail, and record-keeping abilities based on prior experience
• Strong basic laboratory techniques such as micropipetting; measuring solutions using volumetric flasks, graduated cylinders; making reagents, mobile phases, and standard solutions; using centrifuges, vortexes, and other equipment in an analytical laboratory
• Outstanding communication skills

Computer software skills (MS Word, Excel and PowerPoint)

• One year of Laboratory Data Management System (LDMS) experience
• Prior knowledge in FDA Good Laboratory Practices (GLP) and NIH DAIDS Clinical
• Knowledge of the basic principles in chemistry
• Strong lab book preparation and documentation skills
• Pharmacology Quality Assurance (CPQA) regulations

The University of California, San Francisco (UCSF) is a leading university dedicated to promoting health worldwide through advanced biomedical research, graduate-level education in the life sciences and health professions, and excellence in patient care. It is the only campus in the 10-campus UC system dedicated exclusively to the health sciences. We bring together the world’s leading experts in nearly every area of health. We are home to five Nobel laureates who have advanced the understanding of cancer, neurodegenerative diseases, aging and stem cells.

UCSF is a diverse community made of people with many skills and talents. We seek candidates whose work experience or community service has prepared them to contribute to our commitment to professionalism, respect, integrity, diversity and excellence – also known as our PRIDE values.

In addition to our PRIDE values, UCSF is committed to equity – both in how we deliver care as well as our workforce. We are committed to building a broadly diverse community, nurturing a culture that is welcoming and supportive, and engaging diverse ideas for the provision of culturally competent education, discovery, and patient care. Additional information about UCSF is available at diversity.ucsf.edu

Join us to find a rewarding career contributing to improving healthcare worldwide.

The University of California San Francisco is an Equal Opportunity/Affirmative Action Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, age, protected veteran or disabled status, or genetic information.

Campus

009617 SRA 2 NEX

Research and Scientific

University Professional Technical Employees – Research Support Professionals Unit (UPTE-RX)

Career

100%

Parnassus Heights (SF)

Days

8 Hours

Monday-Friday, 8a-5p